Can Dogs Take Promethazine? Essential Things You Need To Know | Guide 2023

Dogs can experience a variety of health issues just like humans, and just like humans, they can be treated with medication.

Some medications that are safe for people are not necessarily safe for dogs, and one such drug is promethazine.

But Can Dogs Take Promethazine? The answer is Yes, dogs can take promethazine but it is not recommended without a vet’s approval.

It is a medication that is used to treat many different conditions. In some cases, it can be used to help dogs relax and calm down.

However, it is important to understand the potential risks and side effects associated with promethazine before giving it to your dog.

This blog post will explore the use of promethazine for dogs, along with its potential risks and side effects associated with its use and what you should know before giving it to them. So stay tuned.

Can Dogs Take Promethazine

Yes, They can but it is not recommended without a vet’s approval.

What Is Promethazine And What Are Its Uses?

Promethazine is one of the most commonly used medications to treat nausea, vomiting, motion sickness, allergies, and hives. It can also be used to treat anxiety in dogs.

Promethazine is used for many different purposes, but the concern when it comes to using promethazine for dogs is that it can be dangerous and harmful if used improperly.

It’s important to understand how this medication works so you know whether or not your dog can benefit from the use of promethazine.

  • Promethazine is an antihistamine and a sedative, which means it works to reduce the effects of histamine in the body. Histamine is responsible for triggering allergy symptoms (constricted blood vessels, watery eyes, runny/stuffy nose), and it also plays a role in motion sickness.
  • Promethazine can be used to treat symptoms of allergies and motion sickness in dogs.
  • Promethazine works by blocking the effects of histamine in the body, which means it can work to reduce allergy symptoms and motion sickness. The antihistamine and sedative properties of this drug help it work as an effective treatment for allergies and motion sickness.
  • It is also sometimes used to control the symptoms of canine epilepsy in dogs.

Can Dogs Take Promethazine

What Are The Side Effects Of Promethazine In Dogs?

Promethazine can cause drowsiness, which means it should not be given to your dog before driving or handling heavy equipment. Side effects are almost always mild but can include

  • Shivering or trembling
  • Drooling
  • Dry mouth
  • Joint pain
  • Excessive Urination

Rare side effects include

  • Breathing problems (especially with high doses)
  • Fever
  • Seizures
  • Confusion

However, promethazine can also have dangerous side effects in dogs, especially when used in combination with other medications or supplements.

To ensure your dog’s safety, always consult with your veterinarian before giving them any new medication.

How Often Can I Give My Dog Promethazine?

It is important to understand that even though promethazine can be a very effective treatment for certain conditions, it should not be used regularly without a vet’s approval.

In some cases, your veterinarian may recommend giving your dog promethazine daily or on an ongoing basis.

If this is the case, you should monitor their behavior carefully and alert your vet if they start to display any concerning changes or side effects.

When used on its own and for a short period of time (a few days), the use of promethazine in dogs is generally safe and well-tolerated.

However, when used over an extended period of time, it can become habit-forming and trigger withdrawal symptoms when stopped.

It’s important to understand that promethazine should never be used as a substitute for veterinary care.

It is only one part of an effective treatment plan, and it should only be used in combination with a vet’s recommendations.

How Much Promethazine Can A Dog Take?

The average dose of promethazine for dogs is between 12.5-25 mg for every 30 pounds of body weight, given once daily.

It is important to remember that the dose will vary based on your dog’s weight and severity of symptoms.

It is also necessary to keep in mind that this medication can be dangerous if used improperly.

Will Promethazine Make My Dog Sleepy?

If your dog is given a typical dosage of promethazine for dogs, it will probably make them feel drowsy and lethargic.

Because this drug has a sedative effect, it may also reduce anxiety and promote calmness in dogs that are restless or overly excited.

Will Promethazine Make My Dog Tired?

As with dogs, this medication can promote calmness and relaxation in humans if used at the correct dosage.

It’s important to remember that this drug has a sedative effect, so it may also have an impact on your dog if they are not receiving the correct dosage.

How Much Promethazine Syrup Should I Give My Dog?

Promethazine dosing for dogs is weight-based.

In other words, the dose is based on your dog’s weight in pounds. In general, the average promethazine dosage for dogs is between 12.5-25 mg depending on the dog’s weight.

For example, a promethazine dosage of 10 mg/10 pounds could be given to a 20-pound dog, but not to a 30 pound dog. Promethazine can be given once daily because that is usually the recommended dosage.

This is because of the fact that there is no such thing as one standard dose. It’s important to consult with your veterinarian before giving this medication to your dog so you can get an accurate dose for your pet.

When Should You Give Your Dog Promethazine?

Promethazine is a motion sickness drug that acts as a sedating antihistamine. It should be given just prior to travel, not on a regular basis for allergies.

Your vet may prescribe Promethazine if your dog’s motion sickness cannot be controlled by other methods or medications or if you need to have your dog sedated for a plane or car ride because of anxiety.

Promethazine is not for chronic use and usually should only be given to your dog on the day of travel. The drug comes in syrup form and most dogs will eat it right off their food.

What Precautions Should I Take When Giving Promethazine To My Dog?

Promethazine HCL comes with many precautions. Do not use if your pet is already taking central nervous system depressants such as barbiturates, tranquilizers, or anti-depressants as they can potentiate the effects of Promethazine.

Use with caution if your dog has epilepsy, high blood pressure, or heart disease because sedatives can worsen these conditions.

Use extreme caution when giving the syrup to a long-haired dog with a large neck since the syrup may get stuck in the hair and be difficult to wash out.

Also, because absorption into the body is slower than many other medicines, wait at least two hours after administering before bathing your dog or letting him swim.

How To Administer Promethazine To Your Dog?

Promethazine is usually given to your dog 30 minutes before travel. If this doesn’t work, try 15-20 minutes before traveling next time.

The syrup can be put into your dog’s food or given directly into the mouth on top of the tongue. Be sure to give it when your pet isn’t distracted so he’ll swallow it.

Give the proper dosage for your dog’s weight. For dogs under 25 pounds, give 1 teaspoon; for dogs up to 50 pounds give 2 teaspoons, and for dogs, over 50 pounds give 4 teaspoons (1 tablespoon).

If your dog does not swallow it all down at once, do not try to make him finish it as this may cause stomach problems.

Can I Give Promethazine To My Puppy?

Promethazine is usually prescribed for dogs over the age of 6 months.

However, it may be given to puppies if needed. It’s important to be sure that the puppy is not suffering from any additional health problems because of the sedative effects.

What Is The Difference Between Oral Promethazine And Injectable Promethazine?

Promethazine is available in two forms, oral syrup, and injectable. The only difference between the two are dosage amounts.

Although it is usually given to dogs orally for travel sickness, some vets may prescribe the injectable form if they need fast sedation or for emergencies.

How Do We Give Our Dogs Promethazine Without Vomiting?

For some dogs, giving promethazine can cause vomiting.

If your dog vomits within 30 minutes of taking the medication, the dosage should be divided and given at staggered times throughout the day.

For example, give half in the morning and then again in 4 hours or wait 1 hour after administration to offer food.

Once you get the correct dosage for your dog, you should not have the problem of vomiting again.


Promethazine is often given to dogs for motion sickness.

It can be administered right before travel or given as a one-time dose if your dog becomes nauseous during travel.

It may also be given to dogs for its sedative effects if other methods are not effective or if your dog needs to be sedated for travel.

I hope this article has provided you with all the information you need to make a decision that can dogs take promethazine.

If you still have any questions or concerns leave a comment below.